Cutaneous manifestations of anti-neutrophil cytoplasmic antibody associated vasculitis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a distinct group of systemic with severe multi-organ involvement. It includes three types: granulomatosis polyangiitis (GPA), eosinophilic (EGPA), and microscopic (MPA). Cutaneous manifestations are present at the time presentation in around 35% cases more frequently encountered EGPA than GPA or MPA. They can also occur during course disease mark relapse. be classified into specific non-specific according to presence absence vasculitis, whether not associated granuloma, skin biopsies. The most common vasculitic lesions AAV palpable purpura. Other include hemorrhagic blisters, tender subcutaneous nodules, livedo reticularis/racemosa, painful ulcers that may mimic pyoderma gangrenosum (PG), digital gangrenes. A wide range cutaneous association including urticarial rash, prurigo, sterile pustules, oral lesions. usually organ involvement manifestations. Since other types disorders, attributing them requires meticulous clinical, laboratory, serological correlation. Awareness important for all physicians working field as biopsy provide an easy clue diagnose such cases.